Cerebrovascular Effects of Apolipoprotein E
نویسندگان
چکیده
منابع مشابه
Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease.
Human apolipoprotein E (apoE) has 3 isoforms: apoE2, apoE3, and apoE4. APOE4 is a major genetic risk factor for Alzheimer disease and is associated with dementia in Down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. While apoE4 can induce neuropathology by participating in various cellular and molecular pathways,...
متن کاملPrevalence of Apolipoprotein E Phenotypes in Ischemic Cerebrovascular Disease
coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. Methods: The apolipoprotein E phenotypes of 69 patients (mean±SD age, 72±+11 years) who had suffered completed stroke or a transient ischemic attack and 68 sexand age-matched control subjects free of cerebrovascular disease were determined by isoelectric focusing. The relative frequ...
متن کاملApolipoprotein E polymorphism in cerebrovascular & coronary heart diseases.
The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E). APO E consists of three common alleles, designated as ε2, ε3 and ε4 which code for E2, E3 and E4 proteins respectively resulting in three homozygous (E2/E2, E3/E3, E4/E4) and ...
متن کاملThe Apolipoprotein E e4 Allele and Outcome in Cerebrovascular Disease
Background and Purpose—Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the e4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the e4 allele on outcome. Methods—APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke a...
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gol-e-gohar iron ore mine of sirjan in southern part of iran is a large open pit that operates below the groundwater table and during mining operation, dewatering is required to prevent operation processes from flooding. current operation is going on by digging wells in or out of the pit and pumping to prevent flooding. as a result of the former dewatering operation a vast deep cone of depressi...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2013
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2013.2152